Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization
Our findings reveal a novel hsa_circ_0038737/IGF2BP3/DNPH1 axis driving PARPi resistance in CRPC, offering promising potential biomarkers and therapeutic targets to overcome resistance and improve treatment outcomes in advanced prostate cancer.
Authors
- Tao Feng (ORCID: https://orcid.org/0000-0001-8550-0626)
- Aihetaimujiang Anwaier (ORCID: https://orcid.org/0000-0002-0859-5171)
- Zhe Hong (ORCID: https://orcid.org/0000-0001-5942-4893)
- Dingwei Ye (ORCID: https://orcid.org/0000-0002-6761-5195)
- Qintao Ge (ORCID: https://orcid.org/0000-0001-5040-6699)
- Xi Tian (ORCID: https://orcid.org/0000-0003-1965-0647)
- Wenhao Xu (ORCID: https://orcid.org/0000-0003-4136-5586)
- Zi-Hao Zhang (ORCID: https://orcid.org/0009-0001-0191-1725)
- Shiwei Liu
- Zhongyuan Wang (ORCID: https://orcid.org/0009-0005-7313-0855)
- Xiaojian Qin
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12943-025-02447-y
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Health Bureau
- Shanghai Hospital Development Center
- National Science and Technology Major Project