Aging-related signature stratifies LUAD prognosis and uncovers senescence-induced chemoresistance via NF-κB/RELA activation
This study established a clinically relevant aging-related signature for risk stratification in LUAD and provides mechanistic insights into how aging-driven cellular senescence promotes chemoresistance through RELA/NF-κB pathway activation. Targeting NF-κB signaling may represent a promising therapeutic approach to overcome senescence-associated chemoresistance and improve outcomes for LUAD patients.
Authors
- Yi Zang (ORCID: https://orcid.org/0000-0001-9835-922X)
- Chaoyi Zhu (ORCID: https://orcid.org/0000-0001-9784-7678)
- Zhijun Jie (ORCID: https://orcid.org/0000-0002-0770-468X)
- Jian‐Wen Dong (ORCID: https://orcid.org/0000-0003-2379-554X)
- Xianwen Shang (ORCID: https://orcid.org/0000-0001-6143-9349)
- Jindong Shi (ORCID: https://orcid.org/0000-0003-2611-5263)
- Jia Li (ORCID: https://orcid.org/0000-0002-2941-128X)
- Yue Dong (ORCID: https://orcid.org/0000-0002-9986-409X)
- Tingting Ge (ORCID: https://orcid.org/0009-0004-7195-5418)
- Ying Dong (ORCID: https://orcid.org/0000-0002-7367-8862)
Institutions
- Nanjing Tech University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Jiangsu Yonggang Group (China) (CN)
- Pudong Medical Center (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Institute for Advanced Study (DE)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12931-025-03355-x
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China