Microbiome-metabolome interplay in pancreatic cancer progression: insights from multi-omics analysis
This study suggests a relationship between the microbiome and metabolism in pancreatic cancer. We observed that Pseudomonas contributes to altered amino acid metabolism, but whether this interaction is causal and the mechanisms underlying it remain unclear. Further experimental validation is required before considering microbiome-targeted metabolic interventions as viable therapeutic strategies.
Authors
- Liandong Ji
- Qihan Chen
- Jianbo Yang (ORCID: https://orcid.org/0000-0002-1368-5294)
- Yongguang Tao (ORCID: https://orcid.org/0000-0003-2354-5321)
- Dong Luo (ORCID: https://orcid.org/0000-0003-3995-1404)
- Xuejun Gong
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12943-025-02458-9
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Central South University
- Xiangya Hospital, Central South University