Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate
A chiral-pool strategy was employed to construct nanofiber-like cysteine-derived thiazoline COFs featuring a two-dimensional eclipsed (AA) stacking arrangement. The Cu(ii)@(R)-THZTp achieved 95% yield and 93% ee in asymmetric Henry reactions. Integration with chitosan aerogel enabled gram-scale synthesis of <i>R</i>-salmeterol intermediate (92% yield, 93% ee) with excellent recyclability.
Authors
- Bing‐Jian Yao (ORCID: https://orcid.org/0000-0002-8165-5871)
- Yu‐Bin Dong (ORCID: https://orcid.org/0000-0002-9698-8863)
- Wenbo Xu (ORCID: https://orcid.org/0009-0006-7740-5497)
- Fei Li (ORCID: https://orcid.org/0000-0003-2081-8339)
- Jian Wang (ORCID: https://orcid.org/0000-0002-3298-6367)
- Y. Leng
Institutions
- Shandong Normal University (CN)
- Ministry of Education (ME)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04282h
- Citations
- 2
- Primary Topic
- Covalent Organic Framework Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.04