Melatonin may be an alternative to amifostine in salivary gland protection in irradiated rats
Mel has a salivary radioprotective activity comparable to Ami. The combined use of drugs has not provided a significant therapeutic advantage in preventing salivary inflammatory stress and apoptotic changes. Thus, Mel may be an alternative to Ami to prevent RT-induced salivary gland damage.
Authors
- Oğuz Köse (ORCID: https://orcid.org/0000-0002-0318-2458)
- Sema YILMAZ RAKICI
- Adnan Yılmaz (ORCID: https://orcid.org/0000-0003-4842-1173)
- Mithat Terzi (ORCID: https://orcid.org/0000-0003-2222-2715)
- Meltem Zihni Korkmaz (ORCID: https://orcid.org/0000-0002-2574-0908)
- Tolga Mercantepe (ORCID: https://orcid.org/0000-0002-8506-1755)
- Nur Yorgancilar (ORCID: https://orcid.org/0009-0005-6356-7885)
Institutions
- Recep Tayyip Erdoğan University (TR)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12903-025-06859-6
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Advanced Research Projects Agency