Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial

Compared to atropine, the combination of glycopyrrolate and neostigmine results in less fluctuation in heart rate but a higher incidence of dry mouth, with no significant differences in other complications. Therefore, glycopyrrolate may be preferred in scenarios where hemodynamic stability is prioritized, considering its higher risk of dry mouth.

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Publication Details

Journal
BMC Pediatrics
Published
2025-10-02
DOI
https://doi.org/10.1186/s12887-025-06092-8
Citations
2
Primary Topic
Anesthesia and Sedative Agents
Type
article
Field-Weighted Citation Impact
4.38
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article

Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial

Sisi Wei, Tianxiao Zou, Wei Rong, X. Yang et al.
2 citations
BMC Pediatrics
Anesthesia and Sedative Agents
4.38
article

Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial

Sisi Wei, Tianxiao Zou, Wei Rong, X. Yang, Guoqing Wang, Shenghua Yu, Lulu Ren
article en
2 citations

Abstract

Compared to atropine, the combination of glycopyrrolate and neostigmine results in less fluctuation in heart rate but a higher incidence of dry mouth, with no significant differences in other complications. Therefore, glycopyrrolate may be preferred in scenarios where hemodynamic stability is prioritized, considering its higher risk of dry mouth.

BMC PediatricsVol. 25(1)
Shanghai Jiao Tong University (CN), Ruijin Hospital (CN), Shanghai Children's Hospital (CN)
Openalex Percentile: Top 6%
Anesthesia and Sedative Agents
4.38
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