Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial
Compared to atropine, the combination of glycopyrrolate and neostigmine results in less fluctuation in heart rate but a higher incidence of dry mouth, with no significant differences in other complications. Therefore, glycopyrrolate may be preferred in scenarios where hemodynamic stability is prioritized, considering its higher risk of dry mouth.
Authors
- Sisi Wei (ORCID: https://orcid.org/0000-0001-5959-653X)
- Tianxiao Zou
- Wei Rong (ORCID: https://orcid.org/0000-0002-8550-6574)
- X. Yang (ORCID: https://orcid.org/0000-0002-7481-3149)
- Guoqing Wang (ORCID: https://orcid.org/0000-0002-1711-3656)
- Shenghua Yu
- Lulu Ren
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12887-025-06092-8
- Citations
- 2
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 4.38