Add in a virus: four cases of severe Kawasaki disease and concurrent adenovirus infection
These cases are illustrative of the challenges of distinguishing between acute infections and Kawasaki disease, and managing cases with concurrent infection. We postulate that adenovirus infection may trigger immune dysregulation in at-risk children, resulting in a hyperinflammatory syndrome which is clinically consistent with Kawasaki disease and macrophage activation syndrome.
Authors
- Brian Eley (ORCID: https://orcid.org/0000-0003-0811-0098)
- Diana Hardie
- Leah Githinji (ORCID: https://orcid.org/0000-0003-0480-0868)
- George Comitis (ORCID: https://orcid.org/0000-0001-8464-744X)
- Heloise Buys (ORCID: https://orcid.org/0000-0001-9778-8233)
- Liesl Zühlke (ORCID: https://orcid.org/0000-0003-3961-2760)
- Claire Butters (ORCID: https://orcid.org/0000-0001-8153-6680)
- Kate Webb (ORCID: https://orcid.org/0000-0003-1087-5946)
- Michael J. Harrison (ORCID: https://orcid.org/0000-0002-7869-5573)
- Georgia Dewey
- Zinzile Ngwenyama
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- The Francis Crick Institute (GB)
- Dora Nginza Hospital (ZA)
- Red Cross War Memorial Children's Hospital (ZA)
- Walter Sisulu University (ZA)
- Nelson Mandela University (ZA)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12887-025-05982-1
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Francis Crick Institute
- South African Medical Research Council
- Medical Research Council