Suppressing glutamine metabolism in the pancreatic cancer microenvironment can enhance the anti-tumor effect of CD8 T cells and promote the efficacy of immunotherapy
Inhibition of glutamine metabolism within the pancreatic cancer microenvironment results in reduced apoptosis of immune cells, heightened activation and cytotoxicity of CD8 T cells, and a substantial enhancement in the therapeutic efficacy of immunotherapy.
Authors
- Jianfei Chen (ORCID: https://orcid.org/0000-0003-2370-4222)
- Yisheng Peng (ORCID: https://orcid.org/0000-0002-8331-3429)
- Xiaoli Yang (ORCID: https://orcid.org/0000-0002-1681-2957)
- Si Hui Tan (ORCID: https://orcid.org/0000-0002-0809-0085)
- Jun Fan (ORCID: https://orcid.org/0000-0003-4570-7694)
- Bo Li (ORCID: https://orcid.org/0000-0002-5575-3582)
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0002-9385-8107)
- Rui Wang (ORCID: https://orcid.org/0000-0002-6132-0433)
- Hao Tang (ORCID: https://orcid.org/0000-0003-1709-5889)
- Maoshan Chen (ORCID: https://orcid.org/0000-0002-3827-4969)
Institutions
- Xiamen University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Suizhou Central Hospital (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1599252
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00