Naltrexone in the Treatment of Ketamine Use Disorders: A Case Report and Literature Review

Our findings are consistent with 2 prior reports that have highlighted the use of naltrexone in KUDs. The 2 previous case reports indicated that naltrexone at the dosage of 50 mg/day successfully helped the patients to achieve abstinence. Studies have shown that naltrexone reduces the antidepressant effects of ketamine in treatment-resistant depression, indicating an overlap between the opioid system and ketamine's NMDA receptor activity. Larger, double-blind studies are needed to evaluate naltrexone's efficacy, safety, and optimal dosing for KUDs.