Circulating Molecular Drivers of Bone Remodeling in Pancreatitis
These findings represent the most comprehensive bone metabolism biomarker profiling in pancreatitis to date, revealing stage-specific dysregulation of bone remodeling. Findings suggest a shift toward increased bone resorption and impaired formation with disease progression. Larger longitudinal studies are needed for marker validation, to clarify mechanisms, and guide targeted interventions to reduce bone loss and fracture risk in this high-risk population.
Authors
- Dhiraj Yadav
- Phil A. Hart
- David C. Whitcomb (ORCID: https://orcid.org/0000-0002-4462-1410)
- Rachel L. Hill (ORCID: https://orcid.org/0000-0002-2511-6486)
- Kimberly Stello
- Darwin L. Conwell (ORCID: https://orcid.org/0000-0003-0449-3730)
- Kristen McQuerry (ORCID: https://orcid.org/0000-0002-0130-4335)
- Kelsey Karnik
- Madhumathi Rao (ORCID: https://orcid.org/0000-0001-7165-9409)
Institutions
- University of Kentucky (US)
- University of Pittsburgh (US)
- The Ohio State University Wexner Medical Center (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.14309/ctg.0000000000000926
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00