Association Between Chitinase 3-Like Protein 1 and Severe Nonalcoholic Fatty Liver Disease: A Large Prospective Cohort Study in UK Biobank
Elevated CHI3L1 levels are associated with an increased risk of severe NAFLD. These findings suggest that CHI3L1 may serve as a novel biomarker and potential contributor to NAFLD progression, offering insights into the inflammatory and metabolic mechanisms underlying the disease.
Authors
- Jiafeng Zou
- Haoye Zhang (ORCID: https://orcid.org/0009-0005-8324-5269)
- Anguo Liu
- Zhenguo Liu (ORCID: https://orcid.org/0000-0003-2696-6535)
- Yu Yan (ORCID: https://orcid.org/0000-0001-6697-5482)
Institutions
- University of Maryland, Baltimore (US)
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.14309/ctg.0000000000000929
- Primary Topic
- Phytase and its Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00