IGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation
Here, we provide mechanistic evidence that IGFBP2 act as a critical regulatory factor in the activation of prostate stromal microenvironment and contributes to aggressive PCa progression.
Authors
- Ryohei Yamamoto (ORCID: https://orcid.org/0000-0002-5144-6585)
- Hiroshi Nanjo
- Tomonori Habuchi (ORCID: https://orcid.org/0000-0003-0998-4432)
- Mizuki Kobayashi (ORCID: https://orcid.org/0000-0002-4135-6789)
- Hiromi Sato (ORCID: https://orcid.org/0000-0001-8815-4829)
- Soki Kashima (ORCID: https://orcid.org/0000-0003-4536-3449)
- Takayuki Ikezoe (ORCID: https://orcid.org/0000-0002-7858-278X)
- Mingguo Huang (ORCID: https://orcid.org/0000-0003-1001-3879)
- Yuya Sekine
- Mitsuru Saito (ORCID: https://orcid.org/0000-0003-1653-4309)
- Shintaro Narita
- Kazuyuki Numakura
- Taketoshi Nara (ORCID: https://orcid.org/0009-0005-0605-9972)
- Atsushi Koizumi
Institutions
- Fukushima Medical University (JP)
- Akita University (JP)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12964-025-02414-6
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology