VISTA expressed on tumor cells is regulated by m6A and influences immune microenvironment through STAT3/CCL22 in NSCLC
We conduct a pioneering systematic study on the expression, function, and molecular mechanisms of the VISTA molecule on NSCLC TCs. We propose that in the tumor immune microenvironment, VISTA functions as both an immune checkpoint and a regulator of CD8 + T cell activation/recruitment and Treg recruitment via its expression on TCs.
Authors
- Bei Jiang (ORCID: https://orcid.org/0000-0002-4036-0735)
- Qinpei Cheng
- Kaikai Shen (ORCID: https://orcid.org/0000-0002-5956-501X)
- Tangfeng Lv (ORCID: https://orcid.org/0000-0001-7224-8468)
- Zhangmin Ke
- Bingbing Li (ORCID: https://orcid.org/0000-0001-6140-4189)
- Dong Wang (ORCID: https://orcid.org/0000-0003-3489-915X)
- Hao Xu (ORCID: https://orcid.org/0000-0002-3002-5693)
- Suhua Zhu
- Yong Song
- Qiuli Xu (ORCID: https://orcid.org/0009-0001-7558-1191)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Affiliated Hospital of Nantong University (CN)
- Zhongda Hospital Southeast University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Jiangning Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12967-025-06818-3
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81