Crohn’s disease-like perianastomotic ulcerations after neonatal necrotizing enterocolitis surgery: a case of successful anti-TNF therapy

Early anti-TNF therapy induced rapid and sustained remission in a pediatric patient with DPAU, reinforcing the mechanism that TNF-α-driven inflammation underlies disease pathogenesis. While promising, these findings require validation in larger cohorts. Individualized therapeutic decisions should weigh the risks of recurrence, cost, and long-term biologic safety.