Cerebrospinal fluid neuronal pentraxin levels are associated with tau pathology via microglia–astrocyte signaling in alzheimer’s disease
NPTX proteins are associated with tau-related pathology in AD, and CSF GFAP and sTREM2 may mediate these associations, with their roles potentially differing across stages of disease progression.
Authors
- Wen‐Quan Zou (ORCID: https://orcid.org/0000-0001-8062-0370)
- Xin Chen (ORCID: https://orcid.org/0000-0001-5790-616X)
- Na Jiang (ORCID: https://orcid.org/0000-0001-5730-3465)
- Zi-Hao Zhang (ORCID: https://orcid.org/0009-0001-0191-1725)
- Zehu Sheng
Institutions
- Nanchang University (CN)
- Shanghai University of Sport (CN)
- Dalian Medical University (CN)
- Jiangxi Provincial Academy of Medical Sciences (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Shanghai Research Institute of Sports Science (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12974-025-03545-w
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Alzheimer's Disease Neuroimaging Initiative
- National Natural Science Foundation of China
- Nanchang University