Vitiligo in the Digital Spotlight: A Retrospective Web Search Analysis from Germany (Preprint)

<sec> <title>BACKGROUND</title> Vitiligo is a chronic skin disease with a global prevalence of approximately 1-2%, characterized by depigmented macules. Little is known on the public interest and medical needs in patients with Vitiligo in Germany. Understanding this however is critical for a patient-centered holistic therapeutic management of the disease. </sec> <sec> <title>OBJECTIVE</title> This study aimed to analyze vitiligo-related web search behavior across Germany as a proxy for public awareness. </sec> <sec> <title>METHODS</title> A retrospective longitudinal study was conducted using the Google Ads Keyword Planner to collect monthly search volume data for vitiligo-related terms from October 2019 to May 2023. Keywords were identified in the seven most spoken languages in Germany (German, Turkish, English, Arabic, Russian, and Polish). Seasonal and regional variations were analyzed, along with correlations, with population density, dermatologist availability, and weather patterns. </sec> <sec> <title>RESULTS</title> In total, 7,764,080 vitiligo-related searches were recorded. Most searches (74.8%) addressed general information. Search volume peaked during summer months and correlated positively with temperature and sunshine hours (p &lt; 0.001). Notable regional differences were observed, with the highest search rates in Hamburg, Berlin and Bremen. Rural areas showed higher search volume per 100,000 inhabitants compared to urban areas. </sec> <sec> <title>CONCLUSIONS</title> The findings suggest a strong public interest in vitiligo, particularly during periods of increased skin exposure. The high demand for treatment-related information further reflects the need for accessible, effective care. Web search behavior can offer real-time insight into public awareness and unmet needs, supporting earlier disease recognition, stigma reduction, and targeted educational strategies. </sec>