Trends and cross-country inequalities in schizophrenia from 1990 to 2021, with prediction to 2035: a systematic analysis of the global burden of disease study 2021

The global schizophrenia burden generally increased between 1990 and 2021, with the burden concentrated in young adults. Trends in the schizophrenia burden show regional and national differences and vary by age, sex, period, cohort, and socio-demographic index. This study highlights the challenges, including increasing global burdens and inequalities, which may be instructive for better public health policy development and allocation of healthcare resources. Comprehensive strategies to promote mental health among young adults need to be continually prioritised.