Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM
Our data show that the variability of CatK circulating levels is associated with glucose tolerance status, and with early signs of atherosclerosis in a population with T2DM as well as in non-diabetic individuals. These findings, combined with the established role of CatK in vascular remodeling, suggest that CatK may play a role in the early etiopathogenesis of cardiovascular complications in T2DM.
Authors
- Mariangela Rubino (ORCID: https://orcid.org/0000-0002-0835-6840)
- Mattia Massimino (ORCID: https://orcid.org/0000-0003-3533-939X)
- Angela Palummo
- Francesco Andreozzi (ORCID: https://orcid.org/0000-0001-9375-1513)
- Carolina Averta (ORCID: https://orcid.org/0000-0002-6667-6906)
- Maria Perticone
- Davide Bolignano (ORCID: https://orcid.org/0000-0003-3032-245X)
- Marta Greco (ORCID: https://orcid.org/0000-0003-4192-3891)
- Velia Cassano (ORCID: https://orcid.org/0000-0002-0793-1225)
- Giuseppe Coppolino (ORCID: https://orcid.org/0000-0001-8000-0681)
- Angela Sciacqua (ORCID: https://orcid.org/0000-0003-1674-5317)
- Gaia Chiara Mannino (ORCID: https://orcid.org/0000-0002-6341-4572)
- Giorgio Sesti (ORCID: https://orcid.org/0000-0002-1618-7688)
- Elettra Mancuso (ORCID: https://orcid.org/0000-0002-0562-9196)
Institutions
- Magna Graecia University (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12967-025-07079-w
- Citations
- 1
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- European Commission