<i>In situ</i> synthesis of bioorthogonally catalyzed drugs based on hydrogen-bonded organic frameworks for cancer therapy
A GSH-responsive platform (1+2@Cu-HOF@HA) was built from Cu-TCPP and prodrugs 1 and 2. In tumors, GSH reduces Cu( ii ) to Cu( i ), triggering CuAAC to generate drug 3 (CA-4 analogue) in situ for anti-tumor therapy.
Authors
- Tommy Jiang (ORCID: https://orcid.org/0000-0002-1199-0615)
- Jiarui Qiao
- Jian Zhen Ou (ORCID: https://orcid.org/0000-0002-6971-2634)
- Luwen Zhang (ORCID: https://orcid.org/0000-0002-8876-3947)
- Yan Wang (ORCID: https://orcid.org/0000-0002-2277-7115)
- Xi Wei
- Maolin Pang (ORCID: https://orcid.org/0000-0001-5125-4615)
Institutions
- Guangxi Normal University (CN)
Publication Details
- Journal
- Inorganic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qi01690h
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94