Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023
Analysis of 314 waterfowl Salmonella strains revealed severe multidrug resistance (MDR) and diverse resistance genes (DRGs), with 13 DRGs linked to resistance. China's antibiotic ban reduced targeted resistance, but MDR persists alarmingly via acquired DRGs and adaptation. Continued enforcement may lower aminoglycoside/phenicol resistance, but β-lactam resistance will likely endure, worsened by transcontinental bla<sub>CTX-M</sub> spread. Critically, plasmid co-selection threatens to amplify MDR, demanding genomic surveillance. Mitigation requires boosting policy compliance, developing non-antibiotic therapies, mapping mutations, establishing cross-species barriers, and prioritizing One Health interventions to block resistance spread.
Authors
- Rongxu Li
- Jipei Zhang
- Liu Min-fang
- Bing Yu (ORCID: https://orcid.org/0000-0001-6013-5220)
- Jidang Chen
- Yishan Zhang (ORCID: https://orcid.org/0009-0008-8856-0999)
- Zhichang Yang (ORCID: https://orcid.org/0000-0003-1481-696X)
- Wenhao Li (ORCID: https://orcid.org/0000-0001-5209-8933)
- Jianhong Chen (ORCID: https://orcid.org/0000-0002-9501-5031)
- Jiacheng Zhong (ORCID: https://orcid.org/0009-0003-7124-2664)
- Wanjun Zhu
Institutions
- Foshan University (CN)
- Guangdong Polytechnic of Science and Technology (CN)
- Fosun Pharma (China) (CN)
- Beike Biotechnology (China) (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12866-025-04345-1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Foshan University
- Young Scientists Fund