Investigation of prevalence and phylogenetic classification of Microsporidia MB and insecticide target site insensitivity resistance mutations in Anopheles gambiae s.l. and Anopheles funestus mosquitoes from Busia, Kenya
The present study highlights the occurrence of Microsporidia MB in multiple Anopheles vectors associated with malaria suggesting its broader potential as a vector control tool. The high prevalence of kdr mutations indicate a significant challenge to insecticide-based vector control in the region. Further investigation into the phenotypic expression of insecticide resistance in these populations is important. Results of the phylogenetic analysis suggest a common ancestry for Microsporidia MB isolates from Busia with the Ahero reference one, highlighting shared traits with potential for malaria control.
Authors
- Luna Kamau (ORCID: https://orcid.org/0000-0002-2186-0283)
- Eric Ochomo (ORCID: https://orcid.org/0000-0002-4042-4970)
- Stanley Kitur
- Daniel Kiboi (ORCID: https://orcid.org/0000-0003-0797-7378)
- Jeremy K. Herren (ORCID: https://orcid.org/0000-0003-2239-7275)
- Damaris Matoke-Muhia (ORCID: https://orcid.org/0000-0001-7737-8069)
- Godfrey Nattoh (ORCID: https://orcid.org/0000-0003-1573-2477)
- Herzel Tiffany Wandera
- Manase Onyango Aloo
- Sharon Nyagaka
- Malvin Atieno Otieno
Institutions
- International Centre of Insect Physiology and Ecology (KE)
- Liverpool School of Tropical Medicine (GB)
- Jomo Kenyatta University of Agriculture and Technology (KE)
- Kenya Medical Research Institute (KE)
- Kaimosi Friends University (KE)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12866-025-04324-6
- Primary Topic
- Insect symbiosis and bacterial influences
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Glasgow