Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence
Our results support a potential implication of miR-146a-5p, miR-21-5p, miR-4707-3p, miR-1908-5p, and miR-6810-3p to CRC risk. However, their downstream effects should be elucidated before they can be utilized as preventive targets.
Authors
- Sarah J. Lewis (ORCID: https://orcid.org/0000-0003-4311-6890)
- Amanda I. Phipps (ORCID: https://orcid.org/0000-0002-1446-2201)
- Bethany Van Guelpen (ORCID: https://orcid.org/0000-0002-9692-101X)
- Victor Moreno
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- Rima Mustafa (ORCID: https://orcid.org/0000-0003-2623-5337)
- Andrew J. Pellatt (ORCID: https://orcid.org/0000-0002-0127-9790)
- Rish K. Pai (ORCID: https://orcid.org/0000-0002-2692-221X)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-2759-9247)
- Daniel Sobieski
- Richard Michael Martin (ORCID: https://orcid.org/0000-0002-7992-7719)
- Stephanie L. Schmit (ORCID: https://orcid.org/0000-0001-5931-1194)
- Temitope O. Keku (ORCID: https://orcid.org/0000-0003-4019-3903)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Emmanouil Bouras (ORCID: https://orcid.org/0000-0003-1489-5506)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Christos Papagiannopoulos (ORCID: https://orcid.org/0000-0003-4030-882X)
- Caroline Y. Um (ORCID: https://orcid.org/0000-0001-5449-6230)
- Konstantinos K Tsilidis
- Anna H. Wu
- Abbas Dehghan
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
Institutions
- Broad Institute (US)
- Intermountain Healthcare (US)
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Cleveland Clinic (US)
- Harvard University (US)
- German Cancer Research Center (DE)
- University of Ioannina (GR)
- Vanderbilt University (US)
- University of Washington (US)
- Heidelberg University (DE)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Open Data Institute (GB)
- University of Bristol (GB)
- Cleveland Clinic Lerner College of Medicine (US)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Institut Català d'Oncologia (ES)
- NIHR Bristol Biomedical Research Centre (GB)
- Mayo Clinic in Arizona (US)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- Umeå University (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12916-025-04311-8
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- NIHR Bristol Biomedical Research Centre
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Bristol