Non–β-Lactam Antibiotic Use, β-Lactam Allergy, and Surgical Site Infections
This cohort study found that β-lactam prophylaxis was associated with significantly lower SSI rates than non-β-lactam agents, and a reported β-lactam allergy did not independently predict infection risk. Implementation of an allergy-focused stewardship guideline was associated with a marked reduction in non-β-lactam use, underscoring the importance of precise allergy assessment to avoid unnecessary alternative prophylaxis.
Authors
- Louise‐Marie Oleksiuk (ORCID: https://orcid.org/0000-0003-2869-2072)
- Andrej A. Petrov (ORCID: https://orcid.org/0000-0002-2574-4626)
- Erin K McCreary
- Rohit Prem Kumar (ORCID: https://orcid.org/0009-0003-4657-2864)
- Yue-Fang Chang
- Robert M. Friedlander (ORCID: https://orcid.org/0000-0003-4423-9219)
- Jennifer Holder‐Murray (ORCID: https://orcid.org/0000-0003-0030-9297)
- Nitin Agarwal (ORCID: https://orcid.org/0000-0003-0256-3897)
- Victoria Crall
- David Kojo Hamilton (ORCID: https://orcid.org/0009-0009-7713-7252)
- Prateek Agarwal (ORCID: https://orcid.org/0000-0001-6554-4736)
Institutions
- University of Pittsburgh (US)
- Pulmonary and Allergy Associates (US)
- University of Pittsburgh Medical Center (US)
- Neurological Surgery (US)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1001/jamasurg.2025.3789
- Citations
- 4
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 5.58