Mechanism of GPR173-Mediated Suppression of TNBC Proliferation and Metastatic Potential via GnRHR Upregulation
Based on these in vitro data, GPR173 likely constrains the pro-proliferative, pro-migratory, and pro-invasive phenotypes of TNBC cells by enhancing GnRHR signaling. These findings highlight GnRHR and GPR173 as potential therapeutic targets for TNBC.
Authors
- Chao Han (ORCID: https://orcid.org/0000-0002-6869-0701)
- Xiang Lu (ORCID: https://orcid.org/0000-0002-7906-6701)
- Caiping Chen (ORCID: https://orcid.org/0000-0003-4075-5427)
- Dan Xing (ORCID: https://orcid.org/0009-0008-9778-445X)
- Li Xue
Institutions
- Zhejiang Chinese Medical University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Clinical Medicine Insights Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/11795549251380919
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00