The effect of general anesthetics on neutrophil-like differentiated HL60 cells: sevoflurane activates the mitochondrial function to promote their bactericidal action
We investigated the effects of three anesthetics on the mitochondrial and bactericidal functions of differentiated HL60 cells. Our results indicate that sevoflurane activates mitochondrial function in differentiated HL60 cells, promotes the production of reactive oxygen species, and enhances bactericidal activity.
Authors
- Mayu Ooi
- Satoshi Mizobuchi (ORCID: https://orcid.org/0000-0003-2059-3272)
- Norihiko Obata
- Yuki Nomura (ORCID: https://orcid.org/0000-0003-4644-2413)
- Daichi Fujimoto (ORCID: https://orcid.org/0000-0002-9864-9910)
- Kosuke Asei
Institutions
- Kobe University (JP)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102272
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00