Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer's disease <i>post mortem</i> brains
Neuroinflammation and metabolic function are worse with Alzheimer's disease (AD). Female brains exhibit more distinct changes in metabolic signaling than males. Female brains have worse metabolic changes with AD. Harmful inflammatory and mitochondrial signaling may promote AD.
Authors
- Aleksandar Necakov (ORCID: https://orcid.org/0000-0001-7080-2859)
- Ahmad Mohammad
- Paula Duarte‐Guterman (ORCID: https://orcid.org/0000-0002-1695-8147)
- Evangelia Tsiani (ORCID: https://orcid.org/0000-0003-4218-5851)
- Robert W. E. Crozier (ORCID: https://orcid.org/0000-0002-2146-5769)
- James Adam
- Lucas Maddalena (ORCID: https://orcid.org/0000-0001-6411-4259)
- Jeffrey A. Stuart (ORCID: https://orcid.org/0000-0001-5894-0300)
- Gaynor E. Spencer (ORCID: https://orcid.org/0000-0001-8927-6844)
- Rebecca E. K. MacPherson (ORCID: https://orcid.org/0000-0002-1577-2658)
- Alex Yang
Institutions
- Brock University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70645
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada