Renal TRPM3 Channels Regulate Blood Pressure via Tubuloglomerular Feedback and Plasma Volume Control
TRPM3 channels contribute to BP regulation by modulating kidney function. Blunted tubuloglomerular feedback in <i>Trpm3</i>-KO mice disrupts NaCl reabsorption, leading to hypovolemia and lower BP. Thus, renal TRPM3 channels may serve as promising targets for BP regulation.
Authors
- José R. López‐López (ORCID: https://orcid.org/0000-0002-3870-421X)
- Karel Talavera (ORCID: https://orcid.org/0000-0002-3124-138X)
- Jorge Rojo-Mencía (ORCID: https://orcid.org/0009-0004-8603-219X)
- M. Teresa Pérez‐García (ORCID: https://orcid.org/0000-0001-8540-8117)
- Pilar Cidad (ORCID: https://orcid.org/0000-0002-6338-7738)
- Marycarmen Arévalo‐Martínez (ORCID: https://orcid.org/0000-0002-3162-4807)
- Lucía Benito-Salamanca
- Lucía Alonso Carbajo (ORCID: https://orcid.org/0000-0001-6613-1546)
Institutions
- Universidad de Valladolid (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Cellular Research (United States) (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25790
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Universidad de Valladolid
- Junta de Castilla y León
- Agencia Estatal de Investigación