Impact of Acute Myeloid Leukemia-Derived Extracellular Vesicles on Expression of <i>CTNNB1, TGF-β,</i> and <i>VEGF</i> Genes in Bone Marrow Mesenchymal Stem Cells: Insights into Leukemia Pathogenesis.
These findings can suggest that AML-derived EVs modulate the BME by promoting BMSC survival and upregulating pro-leukemic genes at an optimal dose, offering a potential therapeutic target for AML treatment.
Authors
- Radman Mazloomnejad (ORCID: https://orcid.org/0000-0001-8888-299X)
- Mahdieh Mehrpouri
- Zahra Nazari (ORCID: https://orcid.org/0000-0003-3951-7798)
- Mohammad Hossein Mohammadi (ORCID: https://orcid.org/0000-0002-8697-1371)
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-09
- DOI
- https://doi.org/10.22074/cellj.2025.2040586.1667
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00