SOX4-Mediated Post-transcriptional Suppression of PTEN via miR-106b∼25 Cluster Contributes to Prostate Cancer Aggressiveness
SOX4 suppresses PTEN through the transcriptional upregulation of miR-106b∼25, rendering tumors sensitive to combined inhibition of SOX4 and PI3K-AKT in prostate cancer.
Authors
- Weiqing Wang
- Bo Han (ORCID: https://orcid.org/0000-0003-4966-1398)
- Jing Hu (ORCID: https://orcid.org/0000-0001-7604-6732)
- Feifei Sun (ORCID: https://orcid.org/0000-0001-9304-0244)
- Lin Gao (ORCID: https://orcid.org/0000-0002-6913-2410)
- Ping Liu (ORCID: https://orcid.org/0000-0003-0133-6860)
- Hui Liu (ORCID: https://orcid.org/0009-0009-1209-3543)
- Meng Wang (ORCID: https://orcid.org/0009-0005-7745-630X)
- Baozhen Wang
Institutions
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- Shandong University (CN)
- Peking University (CN)
- Jinan Maternity And Care Hospital (CN)
- Peking University People's Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1158/1541-7786.mcr-25-0471
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00