ADME Profile Calculation and Drug Similarity Study of New 1,2,4-Triazole Derivatives Containing 2-Bromo-5-Methoxyphenyl Radical
Structural modifications significantly influenced ADME profiles, with thiols and thioacetic acids showing favorable drug-like properties. High-lipophilicity esters may require optimization. These findings support the potential of these triazole derivatives as drug candidates, warranting further pharmacological studies.
Authors
- S. M. Kulish (ORCID: https://orcid.org/0000-0003-0545-993X)
- R. О. Shcherbyna (ORCID: https://orcid.org/0000-0002-9742-0284)
- Oleksandra Cherchesova (ORCID: https://orcid.org/0000-0001-9798-7128)
- Volodymyr Salionov (ORCID: https://orcid.org/0000-0003-4914-0509)
- Mykola Skoryi
Publication Details
- Journal
- Česká a slovenská farmacie
- Published
- 2025-10-02
- DOI
- https://doi.org/10.36290/csf.2025.024
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00