Decoding adipose–brain crosstalk: Distinct lipid cargo in human adipose‐derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease
Human adipose-derived extracellular vesicles (EVs) from obese individuals exhibit distinct lipidomic profiles. EV lipids modulate amyloid-β (Aβ) 40 and Aβ42 aggregation in a lipid-type- and concentration-dependent manner. Lysophosphatidylcholine (LPC) and sphingomyelin (SM) species from obese EVs significantly deregulate Aβ fibrillization in vitro. EV lipid cargo links peripheral metabolic state to amyloid pathology in Alzheimer's disease.
Authors
- Bill Chan
- Jianting Sheng (ORCID: https://orcid.org/0000-0003-3532-3259)
- Xilal Y. Rima (ORCID: https://orcid.org/0000-0001-5633-5887)
- Willa A. Hsueh (ORCID: https://orcid.org/0000-0002-7321-4398)
- Michael W.Y. Chan (ORCID: https://orcid.org/0000-0003-1431-322X)
- Dharti Shantaram (ORCID: https://orcid.org/0000-0003-2637-8039)
- Li Yang (ORCID: https://orcid.org/0000-0003-1421-7377)
- Eduardo Reátegui (ORCID: https://orcid.org/0000-0002-8271-8205)
- Xianlin Han (ORCID: https://orcid.org/0000-0002-8615-2413)
- Stephen Wong
- Shaohua Qi
Institutions
- Houston Methodist (US)
- The University of Texas at San Antonio Health Science Center (US)
- Cornell University (US)
- The Ohio State University Wexner Medical Center (US)
- Methodist Hospital (US)
- Longevity Biotech (United States) (US)
- Methodist Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70603
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Cure Alzheimer's Fund
- National Institutes of Health
- University of Texas Health Science Center at San Antonio
- Houston Methodist Research Institute