Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling
Cobalt-catalyzed enantioselective electroreductive cross-coupling of aryl iodides and indole bromides has been developed. This strategy is characterized by mild reaction conditions, high enantioselectivities, and a broad substrate scope. Notably, this approach effectively addresses the challenges associated with indole substrates that do not possess electron-withdrawing substituents at the 2-position, a limitation that remains unresolved in other strategies.
Authors
- Cong Ma (ORCID: https://orcid.org/0000-0001-7568-1347)
- Ping Fang (ORCID: https://orcid.org/0000-0002-3421-2613)
- Shi-Shuo Xu
- Tian‐Sheng Mei (ORCID: https://orcid.org/0000-0002-4985-1071)
- Jianfeng Guo (ORCID: https://orcid.org/0000-0003-2201-3219)
Institutions
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1021/jacs.5c11094
- Citations
- 6
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 5.62