Neuroprotective role of rice bran extract and its constituents in a neuroinflammatory mouse model
RBE exerts neuroprotective effects potentially through activation of the PPARγ pathway, as evidenced by CD36 upregulation and Aβ reduction. The enrichment of RBE in polyunsaturated fatty acids (PUFAs), along with the observed increase in their brain-penetrant metabolites (EPA and DHA), suggests these lipids may contribute to the cognitive benefits of RBE.
Authors
- Mohammad Abdel‐Halim (ORCID: https://orcid.org/0000-0003-1326-4219)
- Reham M. Abdel‐Kader (ORCID: https://orcid.org/0000-0003-3584-0045)
- Ola A. Heikal (ORCID: https://orcid.org/0000-0003-3320-6884)
- Sarah M. Abou El-Nagah
Institutions
- National Research Centre (EG)
- National Water Research Center (EG)
- German University in Cairo (EG)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12906-025-05097-1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academy of Scientific Research and Technology
- Science and Technology Development Fund