Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank
Our study found that depression is consistently associated with multiple inflammation-related physical health conditions, although associations did not persist after adjustment for lifestyle factors and baseline physical condition count. Further research is needed to explore underlying mechanisms, including inflammatory biomarkers and modifiable lifestyle factors on the causal pathway.
Authors
- Shuvajit Saha (ORCID: https://orcid.org/0000-0001-5185-7440)
- Regina Prigge (ORCID: https://orcid.org/0000-0002-0489-684X)
- Caroline Jackson (ORCID: https://orcid.org/0000-0002-2067-2811)
- Kelly Fleetwood (ORCID: https://orcid.org/0000-0002-1382-3095)
- Philip A. I. Guthrie
Institutions
- University of Edinburgh (GB)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12888-025-07337-7
- Primary Topic
- Cardiac Health and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- Medical Research Council