Detection of AcrAB efflux pump mediated ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae in Nepal
Clinical isolates of E. coli and K. pneumoniae exhibited alarmingly high MDR rates with substantial resistance to commonly prescribed antibiotics in Nepal. We also observed a notable presence of EP-mediated resistance in these isolates. These findings highlight the urgent need for enhanced AMR surveillance (including resistance marker screening and genomic surveillance) and development of evidence-based antibiotic stewardship programs to address the growing burden of MDR Nepal.
Authors
- Bimal Sharma Chalise (ORCID: https://orcid.org/0000-0003-2941-8307)
- Mya Myat Ngwe Tun (ORCID: https://orcid.org/0000-0002-8986-6307)
- Yogendra Shah (ORCID: https://orcid.org/0000-0002-0820-4556)
- Sandesh Rimal (ORCID: https://orcid.org/0000-0002-8064-3625)
- Narayan Sharma Bashyal (ORCID: https://orcid.org/0000-0001-7764-7644)
- Shyam Prakash Dumre (ORCID: https://orcid.org/0000-0002-4072-0745)
- Manisha Rawal
- Bijay Kumar Sharma
- Subi Kharel
- Babita Neupane
Institutions
- Planetary Science Institute (US)
- Tribhuvan University (NP)
- Grande International Hospital (NP)
- Sukraraj Tropical & Infectious Disease Hospital (NP)
- Nagasaki University (JP)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12879-025-11555-5
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Tribhuvan University