Associations of proinflammatory cytokines of visceral adipose tissue with metabolic disorders in abdominal obesity

The aim . To identify associations between proinflammatory cytokines of visceral adipose tissue with metabolic disorders in abdominal obesity. Materials and methods . The study was conducted on 101 people aged 25–65 years. Questionnaires, anthropometry, blood pressure measurements, as well as fasting blood sampling and visceral adipose tissue biopsies during elective surgery were conducted. Enzymatic methods were used to determine the parameters of the lipid profile and glucose in the blood. Homogenates were prepared from biopsies of visceral adipose tissue. The level of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocytic chemoattractant protein-1 (MCP-1) was determined in blood and obtained homogenates of adipose tissue by multiplex analysis. Results . A weak positive relationship was found between serum IL-6 levels and adipose tissue. A weak positive relationship was found between IL-6 visceral adipose tissue and the VAI index, as well as between MCP-1 visceral adipose tissue and the LAP and VAI indices. The level of MCP-1 in visceral adipose tissue is directly associated with the LAP insulin resistance index (6,255 [1,648; 10,862], p = 0.008), TNF-α – with the VAI insulin resistance index (1,076 [0.335; 1,817], p = 0.005). Conclusion . Of the proinflammatory cytokines we studied, an association with insulin resistance was shown for MCP-1 and TNF-α visceral adipose tissue. At the same time, MCP-1 is directly associated with the LAP index, and TNF-α is directly associated with the VAI index.