Inhibition of the METTL3/m6A/miR-34a-5p axis suppresses trigeminovascular activation in nitroglycerin-induced migraine via the Wnt/β-catenin pathway
METTL3 contributes to migraine pathogenesis through m<sup>6</sup>A-dependent upregulation of miR-34a-5p, which suppresses the Wnt1/β-catenin axis and promotes TGVS activation. Targeting this pathway may offer new therapeutic avenues for migraine.
Authors
- Shengdong He (ORCID: https://orcid.org/0000-0001-5739-4619)
- Can He (ORCID: https://orcid.org/0000-0002-4216-6848)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-4387-9399)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-0574-5952)
- Jiabi Li
- Mingbo Shao
Institutions
- Guangxi University (CN)
- Guangdong Medical College (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s10194-025-02144-7
- Citations
- 3
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 2.74