Co-Stimulatory and Immune Checkpoint Molecule Expression on Peripheral Immune Cells Differs Age Dependently Between Healthy Donors and Patients with Head and Neck Squamous Cell Carcinoma
This study sheds light on the changing co-stimulatory molecule/ICM expression regarding the patient's age and reveals an increase in most immune checkpoint molecules for HNSCC patients according to their age. This new evidence is valuable in ensuring individualized therapeutic approaches in the increasingly relevant field of checkpoint inhibition, even in old age.
Authors
- Franziska Oliveri (ORCID: https://orcid.org/0000-0002-3280-448X)
- Julius Vahl (ORCID: https://orcid.org/0000-0002-4481-7085)
- Patrick J. Schuler (ORCID: https://orcid.org/0000-0002-1065-8709)
- Ayla Grages
- Cornelia Brunner (ORCID: https://orcid.org/0000-0002-6456-5508)
- Adrian von Witzleben (ORCID: https://orcid.org/0000-0001-6766-4758)
- Simon Laban (ORCID: https://orcid.org/0000-0001-6732-7137)
- Matthias Brand (ORCID: https://orcid.org/0009-0007-9722-8771)
- Marie‐Nicole Theodoraki (ORCID: https://orcid.org/0000-0002-5491-1593)
- Thomas K. Hoffmann (ORCID: https://orcid.org/0000-0001-5127-3779)
- Jens Greve (ORCID: https://orcid.org/0000-0001-8373-6395)
- Lisa K. Puntigam
Institutions
- Universität Ulm (DE)
- University Hospital Ulm (DE)
- Technische Hochschule Ulm (DE)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3390/cancers17193215
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Universität Ulm