Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation
Our results indicate that low WSS-induced endothelial cell iron metabolism abnormalities, by inducing arterial wall iron accumulation and abnormal expression of iron metabolism-related proteins, promote the occurrence and development of atherosclerosis. The use of iron chelators can alleviate the onset and progression of low WSS-induced atherosclerosis.
Authors
- Biao Zhao (ORCID: https://orcid.org/0009-0006-4309-5697)
- Jing Cai (ORCID: https://orcid.org/0000-0002-0302-9998)
- Zhenxi Zhang
- Kuanyu Li (ORCID: https://orcid.org/0000-0001-9738-049X)
- Zhipeng Chen (ORCID: https://orcid.org/0000-0002-7789-5477)
- Tong Qiao (ORCID: https://orcid.org/0000-0003-2695-2555)
- Lei Zheng (ORCID: https://orcid.org/0000-0002-8342-5236)
- Liu Yang
- Chen Cheng (ORCID: https://orcid.org/0009-0001-1066-5992)
- Run Ji
- Yun Liu (ORCID: https://orcid.org/0000-0003-4377-1211)
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1161/atvbaha.125.322495
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00