Pharmacological Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation
Taken together, this study demonstrates that pharmacological inhibition by liproxstatin-1 mitigates macrophage-dependent ferroptosis, contributing to the inhibition of aortic inflammation and remodeling during AAA formation.
Authors
- Michael Spinosa
- Paolo Bellotti (ORCID: https://orcid.org/0000-0003-4839-8807)
- Timothy J. Garrett (ORCID: https://orcid.org/0000-0003-1623-009X)
- Manasi N. Kamat (ORCID: https://orcid.org/0000-0002-6031-0794)
- Ashish K. Sharma (ORCID: https://orcid.org/0000-0002-1234-6039)
- Joseph B. Hartman (ORCID: https://orcid.org/0009-0006-5107-2188)
- Jonathan R. Krebs (ORCID: https://orcid.org/0000-0003-1956-9988)
- Gilbert R. Upchurch (ORCID: https://orcid.org/0000-0002-4679-8623)
- Jeff Arni C. Valisno (ORCID: https://orcid.org/0000-0002-5486-4328)
- Walker Ueland (ORCID: https://orcid.org/0009-0008-2870-7952)
- Guoshuai Cai (ORCID: https://orcid.org/0000-0002-5331-1297)
- Denny Joseph Manual Kollareth (ORCID: https://orcid.org/0000-0002-3599-3570)
- Adithan Aravinthan (ORCID: https://orcid.org/0000-0001-7086-2616)
- Gang Su
- Shiven Sharma
Institutions
- University of Florida Health (US)
- University of Florida (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1161/atvbaha.125.323269
- Citations
- 1
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52