Comorbidity burden in elderly high-grade glioma patients: impact on radiotherapy outcomes
The ACCI showed limited and inconsistent prognostic value in elderly glioblastoma patients, while diabetes emerged as the only consistent comorbidity predictor of OS and PFS. These findings suggest that comorbidity burden may influence outcomes but underscore the need for larger studies to clarify the role of the ACCI in treatment stratification.
Authors
- Chiara Negwer (ORCID: https://orcid.org/0000-0003-2997-969X)
- Claire Delbridge (ORCID: https://orcid.org/0000-0003-4339-6917)
- Kai Joachim Borm (ORCID: https://orcid.org/0009-0005-8580-890X)
- Benedikt Wiestler (ORCID: https://orcid.org/0000-0002-2963-7772)
- Friederike Schmidt‐Graf (ORCID: https://orcid.org/0000-0002-3515-4427)
- Helen X. Hou (ORCID: https://orcid.org/0009-0007-3326-4319)
- Stephanie Elisabeth Combs (ORCID: https://orcid.org/0000-0002-6934-2864)
- Arthur Wagner (ORCID: https://orcid.org/0000-0001-9947-2240)
- Denise Bernhardt (ORCID: https://orcid.org/0000-0001-5231-9097)
- Jan Caspar Peeken (ORCID: https://orcid.org/0000-0003-2679-9853)
- Igor Yakushev (ORCID: https://orcid.org/0000-0003-4764-798X)
- Valeriya Sackerer
- Bernhard Meyer (ORCID: https://orcid.org/0000-0002-2846-8719)
- Christian Diehl (ORCID: https://orcid.org/0000-0003-1324-8999)
- Sophia M. Leiss (ORCID: https://orcid.org/0009-0007-4463-5314)
- Meike Mitsdörffer
- Daniel Schmottermeyer
Institutions
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1186/s12885-025-14957-5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00