Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis
Restoring hepatic metabolism while controlling inflammation in acutely decompensated cirrhosis remains a major unmet clinical need. By combining HLA-modified human induced pluripotent stem cell-derived liver organoids with granulocyte and monocyte apheresis, we developed a bioartificial liver system that manages inflammation, restores liver function, and promotes regeneration in two rat models of severe liver failure. This therapy could offer an off-the-shelf treatment option for patients with life-threatening liver failure.
Authors
- Hitomi Yamaguchi
- Kentaro Ichimura (ORCID: https://orcid.org/0000-0002-2838-4240)
- Mika Soen
- Yosuke Yoneyama (ORCID: https://orcid.org/0000-0002-9170-2846)
- Takanori Takebe (ORCID: https://orcid.org/0000-0002-6989-3041)
- Kanae Ohtsu
- Chiharu Moriya (ORCID: https://orcid.org/0000-0002-0723-4040)
- G. Mani Subramanian (ORCID: https://orcid.org/0000-0002-5506-9609)
- M Kumagai
- Robert P. Myers
Institutions
- Tokyo Medical and Dental University (JP)
- Kaneka (United States) (US)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1016/j.jhep.2025.08.038
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32