Altered gut microbiota mediates the association between APOE genotype and amyloid-β accumulation in middle-aged adults
Gut microbiome composition mediates the deleterious effect of APOE ε4 on cerebral amyloid deposition, suggesting that microbiome-targeted interventions may mitigate APOE-related risk.
Authors
- Ramachandran Srini Vasan (ORCID: https://orcid.org/0000-0001-7357-5970)
- Alfred K. Njamnshi (ORCID: https://orcid.org/0000-0003-0052-1511)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Yannick N. Wadop (ORCID: https://orcid.org/0000-0002-8955-1874)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Wepnyu Yembe Njamnshi (ORCID: https://orcid.org/0000-0001-5082-7960)
- Alexa Beiser
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Rebecca Bernal
- Jayandra J. Himali
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Université de Yaoundé I (CM)
- The University of Texas at San Antonio Health Science Center (US)
- Universitat Internacional de Catalunya (ES)
- University of Massachusetts Boston (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Central Hospital of Yaoundé (CM)
- Ministry of Public Health (CM)
- South African Brain Research Institute (ZA)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1007/s00415-025-13412-6
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Massachusetts Institute of Technology
- Broad Institute