Prematurity and genetic liability for autism spectrum disorder
Preterm birth may exacerbate multimorbidity present in ASD, which was not due to ASD-associated genetic variants. However, increased ASD-associated rare variants may elevate the likelihood of a preterm child being diagnosed with ASD. Additionally, a polygenic load of ASD-associated variants had an additive role with preterm birth in the predicted probability for ASD, especially for boys. Future integration of genetic and phenotypic data in larger preterm or population-based cohorts will be crucial for advancing early ASD identification in preterm subgroup.
Authors
- Ashraf Yahia (ORCID: https://orcid.org/0000-0002-0376-8264)
- Sven Sandin (ORCID: https://orcid.org/0000-0001-6994-4884)
- Kristiina Tammimies (ORCID: https://orcid.org/0000-0002-8324-4697)
- Ulrika Ådén (ORCID: https://orcid.org/0000-0002-0650-3173)
- Yali Zhang (ORCID: https://orcid.org/0009-0008-6152-2562)
Institutions
- Linköping University (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Mount Sinai Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13073-025-01552-3
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Stiftelsen för Strategisk Forskning
- Karolinska Institutet
- Vetenskapsrådet
- China Scholarship Council
- Sällskapet Barnavård
- National Institutes of Health
- Uppsala Multidisciplinary Center for Advanced Computational Science