Pressure-adjusted static compression: aerobic metabolism and microvascular perfusion in the context of chemotherapy-induced neuropathy
Reduction of oxygen demand represents an important mechanism in interventions targeting prevention of CIPN. PSC, comparable to cryoapplication and IPC attenuates energy metabolism and enhances tissue oxygenation. PSC's impact on the combination of vascular and energy metabolism suggests its potential to alleviate CIPN burden. These findings support PSC's role in reducing acral CIPN through distinct mechanisms.
Authors
- Betty Lischke (ORCID: https://orcid.org/0000-0002-4751-6501)
- Anne Schraplau (ORCID: https://orcid.org/0000-0001-6251-0661)
- Antonia Haspel
- Josef Mohammad
- Ulrich Bernd Keller (ORCID: https://orcid.org/0000-0002-8485-1958)
- Sebastian Ochsenreither (ORCID: https://orcid.org/0000-0001-6024-4312)
- André Schmidt-Lucke
- Helmut Habazettl
- Caroline Schmidt‐Lucke (ORCID: https://orcid.org/0000-0003-2191-3012)
- René Rheimann
Institutions
- MSB Medical School Berlin (DE)
- Medico-Academic Consultings (Germany) (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s40170-025-00409-y
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00