Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation
This study highlights a PRDM1-regulated T cell network that distinguishes high-risk from low-risk plaques and demonstrates the regulatory role of T cell PRDM1 in controlling atherosclerosis, positioning this pathway as a promising therapeutic target.
Authors
- Yuchi Zou
- Baixue Yu
- Erik A.L. Biessen (ORCID: https://orcid.org/0000-0002-6454-8548)
- Marion J. Gijbels (ORCID: https://orcid.org/0000-0002-4906-0384)
- Barend Mees (ORCID: https://orcid.org/0000-0001-6545-5813)
- Emiel P. C. van der Vorst (ORCID: https://orcid.org/0000-0001-5771-6278)
- Samantha Nadeau
- Ljubica Matic (ORCID: https://orcid.org/0000-0002-7294-9667)
- Gislâine A. Martins (ORCID: https://orcid.org/0000-0001-6976-5819)
- Judith C. Sluimer (ORCID: https://orcid.org/0000-0002-0269-4582)
- Han Jin
- Joana Dos Santos (ORCID: https://orcid.org/0000-0002-5551-7678)
- Ulf Hedin (ORCID: https://orcid.org/0000-0001-9212-3945)
- Sanne L. Maas (ORCID: https://orcid.org/0000-0003-1423-8901)
- Claudia Monaco (ORCID: https://orcid.org/0000-0003-1985-4914)
- Chang Lu (ORCID: https://orcid.org/0000-0001-6304-2820)
- Pasquale Maffia (ORCID: https://orcid.org/0000-0003-3926-4225)
- Rosanna Huchzermeier
- Evgueni Smirnov (ORCID: https://orcid.org/0000-0003-2778-6042)
Institutions
- Cedars-Sinai Medical Center (US)
- Karolinska University Hospital (SE)
- Maastricht University Medical Centre (NL)
- Nuffield Orthopaedic Centre (GB)
- Tianjin Medical University General Hospital (CN)
- Maastricht University (NL)
- University of Oxford (GB)
- University Alliance (GB)
- Universitätsklinikum Aachen (DE)
- University of Naples Federico II (IT)
- University of Glasgow (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Amsterdam (NL)
- RWTH Aachen University (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13073-025-01541-6
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Amsterdam University Medical Centers
- British Heart Foundation
- Deutsche Forschungsgemeinschaft
- ZonMw
- Bundesministerium für Bildung und Forschung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Fritz Thyssen Stiftung
- Svenska Sällskapet för Medicinsk Forskning
- Hjärt-Lungfonden
- Vetenskapsrådet
- Maastricht Universitair Medisch Centrum
- China Scholarship Council
- RWTH Aachen University
- Tianjin Municipal Education Commission
- European Research Area Network on Cardiovascular Diseases