The Effectiveness of Tempuyung Leaves' (Sonchus arvensis) Water Fraction in Preventing Inflammation in a Rat Model of Acute Gouty Arthritis

Gouty arthritis is inflammation of the joints that occurs in conditions of chronic hyperuricemia resulting in the deposition of monosodium urate crystals. The management of gout arthritis will emphasize both the acute and chronic phase and the initial drug options for gouty arthritis are non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and colchicine. However, administering chemical drugs can cause various risks and side effects, so alternative treatments are needed, one of which is using herbal medicine. Tempuyung (Sonchus arvensis) is a plant that is often found and easily cultivated in Indonesia, the water fraction of tempuyung leaves contains flavonoids, which can inhibit the pathogenesis of gout arthritis Therefore, this study examined the role of tempuyung (Sonchus arvensis) in preventing gouty arthritis by analyzing the effectiveness of tempuyung leaf fractions in inhibiting the inflammatory cascade. Both the quantitative and qualitative research were done. This research was carried out from March to December 2023 in the Animal House Laboratory, Basic Medical Chemistry, Medical Biotechnology, Faculty of Medicine, Sriwijaya University, Palembang, Special Laboratory for Anatomical Pathology, Barokah Palembang, Integrated Research and Testing Laboratory, Gadjah Mada University, Yogyakarta, and PT Laboratory. Garuda Malang Wing Mission. This research is an experimental study using experimental animals (in vivo) with a post-test control group design. Just as well as colchicine, the water component of tempuyung leaves can reduce inflammation in gouty arthritis. It is desired that more research on the toxicity test of tempuyung leaf water fractions can be conducted in the future to ascertain the safety of these fractions.