Crosstalk between endothelial cells and osteoblasts stimulates ALP via Notch signaling and RANKL/OPG ratio independently of Notch signaling in vitro
Our findings provide novel evidence for the significant role of endothelial cells in bone remodeling, specifically in regulating ALP expression and activity of osteoblasts via the Notch signaling pathway and RANKL/OPG ratio independent of Notch. This study underscores the applicability and significance of multicellular tissue models for studying bone turnover processes in vitro, thereby reducing the reliance on animal testing.
Authors
- Anne Bernhardt (ORCID: https://orcid.org/0000-0002-1903-1929)
- Katharina Wirsig (ORCID: https://orcid.org/0009-0003-0099-528X)
- N. Francois V. Burger (ORCID: https://orcid.org/0000-0002-0874-2143)
Institutions
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s11658-025-00793-9
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Deutsche Forschungsgemeinschaft
- Servier