Safety and efficacy of Tithonia diversifolia (Hemsley) A. Gray extract gel on keloid patient

Keloid is a benign form of dermis tumor formed due to imbalance of collagen deposition and degradation during wound healing. Preclinical studies showed Tithonia diversifolia (Hemsley) A. Gray (T. diversifolia) potency as keloid treatment by inhibiting keloid fibroblast proliferation, collagen deposition, TGFβ1 and VEGF expression. This study aims to examine the safety and efficacy of T. diversifolia extract gel for keloid treatment in keloid patient. Fourteen keloid patients were included in the study with ratio 1:1. The participants received either T. diversifolia extract gel 2% or triamcinolone acetate cream 0.025% for 12 weeks. Evaluation of efficacy was done every 4 weeks until week 12 using Vancouver Scar Score, the patient and observer Scar assessment. Vancouver scar total score was improved in week 12 from baseline in both groups. Improvement from baseline after 12 weeks of treatment also found in patient and observer scar assessment total scale. Those scores on week 12 were similar between those on T. diversifolia extract gel 2% and triamcinolone acetate cream 0.025% treatment. Conclusions: T. diversifolia extract gel 2% is efficacious and safe for keloid treatment.