Regulation of tau protein by circCwc27: shared pathogenic mechanisms in type 2 diabetes mellitus and Alzheimer’s disease
Our findings identify circCwc27 as a novel molecular bridge linking AD and T2DM via Tau upregulation and metabolic impairment. This dual role highlights its potential as both a biomarker and therapeutic target for addressing the shared pathophysiological mechanisms of neurodegeneration and metabolic disease.
Authors
- Shilin Luo
- Lu Shen (ORCID: https://orcid.org/0000-0001-5237-6155)
- Kai Fang (ORCID: https://orcid.org/0000-0002-6228-1974)
Institutions
- Central South University (CN)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Brain Informatics
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s40708-025-00277-8
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province